Aniseed – ESCOP Herbal Monograph 2014

Anisi fructus
Pimpinella anisum L.
Published 2014

Price:   €20
Format: PDF; Instant Download








The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety supporting the therapeutic uses of aniseed.

This herbal substance by definition consists of the whole dry cremocarp of Pimpinella anisum L.

Studies with its main characteristic constituents the essential oil with trans-anethole, cis-anethole and anisaldehyde are included.

The therapeutic indications are dyspeptic complaints such as mild spasmodic gastro-intestinal complaints, bloating, flatulence and catarrh of the upper respiratory tract.

Administration of aniseed addresses: posology; its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose.

In vitro experiments with aniseed oil and extracts demonstrate secretolytic and expectorant, spasmolytic, anaesthetic and oestrogenic activities.

In vivo experiments with aniseed oil and constituents in animals demonstrate secretolytic and expectorant, local anaesthetic, oestrogenic and anti-ulcer properties.

Pharmacokinetics, metabolism, absorption and secretion of orally administered trans-anethole were assessed in animals and humans.

Preclinical safety data for aniseed mainly with trans-anethole were assessed in acute, repeated-dose and reproductive toxicity studies.

Safety data in humans concerned a case of overdose with the essential oil of aniseed.

The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of aniseed and its major constituents. Examples are given below.


  • Anisi fructus
  • Aniseed
  • Pimpinella anisum L.
  • Gastro-intestinal complaints, bloating, flatulence; Catarrh of the upper respiratory tract.


– Kubeczka K-H, von Massow F, Formacek V, Smith MAR. A new type of phenylpropane from the essential fruit oil of Pimpinella anisum L. Z Naturforsch 1976;31b:283-4.
– El-Moghazi AM, Ali AA, Ross SA, Mottaleb MA. Flavonoids of Pimpinella anisum L. growing in Egypt. Fitoterapia 1979;50:267-8.
– Hänsel R, Sticher O, Steinegger E. Anis und Anisöl. In: Pharmakognosie- Phytopharmazie, 6th ed. Berlin-Heidelberg-New York-London: Springer-Verlag, 1999:692-5.
– Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Applied Microbiol 1999;86:985-90.
– Boskabady MH, Ramazani-Assari M. Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol 2001;74:83-8.
This entry was posted in monograph. Bookmark the permalink.

Comments are closed.