Ribis nigri folium
Black Currant Leaf
Ribes nigrum L.
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The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety to support the therapeutic uses of blackcurrant leaf.
This herbal drug by definition consists of the dried leaf of Ribes nigrum L. Studies with its main characteristic constituents, flavonoids as mono- and diglycosides of quercetin, kaempferol and isorhamnetin, and proanthocyanidins are included.
The therapeutic indication is adjuvant in the treatment of rheumatic conditions.
Administration of blackcurrant leaf addresses posology; its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose.
In vitro experiments with blackcurrant leaf extracts or isolated constituents demonstrated anti-inflammatory and anti-oxidant effects. In vivo experiments with blackcurrant leaf extracts or isolated constituents in animals demonstrated anti-inflammatory properties in different models (carrageenan-induced rat paw oedema, cotton pellet-induced granuloma, Freund’s adjuvant-induced arthritis tests), as well as analgesic, diuretic and anti-hypertensive properties.
Preclinical safety data were assessed in toxicity studies.
The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of blackcurrant leaf and its major constituents. Examples are given below.
- Ribes nigrum L.
- Ribis nigri folium
- Blackcurrant Leaf
- Adjuvant treatment of rheumatic conditions
EXAMPLE OF REFERENCES:
– Bonarska-Kujawa D, Cyboran S, Żyłka R, Oszmiański J, Kleszczyńska H. Biological activity of blackcurrant Extracts (Ribes nigrum L.) in relation to erythrocyte membranes. Biomed Res Int 2014; 2014: 783059. http://dx.doi.org/10.1155/2014/783059
– Garbacki N, Tits M, Angenot L, Damas J. Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. BMC Pharmacol 2004; 4: 25. http://dx.doi.org/10.1186/1471-2210-4-25
– Garbacki N, Kinet M, Nusgens B, Desmecht D, Damas J. Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-I and VCAM-I. J Inflamm (Lond) 2005; 2: 9. http://dx.doi.org/10.1186/1476-9255-2-9
– Tits M, Angenot L, Poukens P, Warin R, Dierckxsens Y. Prodelphinidins from Ribes nigrum. Phytochemistry 1992a;31:971-3. http://dx.doi.org/10.1016/0031-9422(92)80196-L
– Vagiri M, Ekholm A, Andersson SC, Johansson E, Rumpunen K. An optimized method for analysis of phenolic compounds in buds, leaves, and fruits of black currant ( Ribes nigrum L.). J Agric Food Chem 2012;60:10501-10. http://dx.doi.org/10.1021/jf303398z