Lady’s Mantle – ESCOP Herbal Monograph 2013 for instant download

Alchemillae herba
Published 2013
Price:   €20
Format: PDF; Instant Download

 

 

 

 

 

 

 

SUMMARY:

The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety to support the therapeutic uses of lady’s mantle. The botanical definition of the herbal drug is the whole or cut, flowering aerial parts of Alchemilla vulgaris L. sensulatiore, a synonym is: Alchemilla xanthochlora Rothm. Studies with its main characteristic constituents which are tannins and flavonoids are included. The therapeutic indications are non-specific diarrhoea and gastrointestinal complaints. Administration of lady’s mantle addresses dosage, its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose. In vitro experiments with lady’s mantle demonstrate antibacterial, astringent, antioxidant, anti-inflammatory and wound healing properties. In vivo experiments in animals demonstrate angioprotective, haemo-rheological and wound healing activities. Clinical data in humans demonstrated its use in patients with minor oral ulcers. Preclinical safety data did not reveal anything on mutagenicity. Clinical safety data showed good tolerability for a topical preparation. The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of lady’s mantle and its major constituents. Examples are given below.

KEYWORDS:

  • Alchemilla vulgaris L. Syn: Alchemilla xanthochlora Rothm.
  • Alchemillae herba
  • Alchemilla / Lady’s Mantle
  • Diarrhoea, non-specific; Gastrointestinal complaints

REFERENCES:

D’Agostino M, Dini I, Ramundo E, Senatore F. Flavonoid glycosides of Alchemilla vulgaris L. Phytother Res 1998;12:S162-S163. http://dx.doi.org/10.1002/(SICI)1099-1573(1998)12:1+<S162::AID-PTR284>3.0.CO;2-P
Geiger C, Rimpler H. Ellagitannins from Tormentillae Rhizoma and Alchemillae Herba. Planta Med 1990;56:585-6. http://dx.doi.org/10.1055/s-2006-961192
Kiselova Y, Ivanova D, Chervenkov T, Gerova D, Galunska B, Ynakova T. Correlation between the in vitro antioxidant activity and polyphenol content of aqueous extracts from Bulgarian herbs. Phytother Res 2006;20:961-5. http://dx.doi.org/10.1002/ptr.1985
Lamaison JL, Carnat A, Petitjean-Freytet C. Teneur en tanins et activité inhibitrice de l’élastase chez les Rosaceae.  Ann Pharm Franç 1990;48:335-40.
Shrivastava R, Cucuat N, John GW. Effects of Alchemilla vulgaris and glycerin on epithelial and myofibroblast cell growth and cutaneous lesion healing in rats. Phytother Res 2007;21:369-73. http://dx.doi.org/10.1002/ptr.2060
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