Meadowsweet – ESCOP Herbal Monograph 2015

Filipendula-1
Filipendulae ulmariae herba
Meadowsweet
Published 2015
Price:   €20
Format: PDF; Instant Download

 

 

 

 

 

 

SUMMARY:

The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety supporting the therapeutic uses of meadowsweet. This herbal drug by definition consists of the whole or cut, dried flowering tops of Filipendula ulmaria (L.) Maxim. (= Spiraea ulmaria L.). Studies with its main characteristic constituents flavonoids, particularly spiraeoside and quercetin derivatives are included. The therapeutic indications are supportive therapy for the common cold and enhancement of renal elimination of water. Administration of meadowsweet addresses posology; its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive;  undesirable effects; overdose. In vitro experiments with meadowsweet demonstrate antimicrobial, anti-inflammatory and immunomodulatory properties. In vivo experiments with animals demonstrate gastroprotective and anticarcinogenic effects. A clinical study demonstrated its local use for the treatment of precancerous changes in patients with cervical dysplasia. Pharmacokinetics indicated conversion by decarboxylation in the gut flora. Preclinical safety data for meadowsweet extract were assessed in animal toxicity studies. The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of meadow sweet and its major constituents. Examples are given below.

KEYWORDS:

  • Filipendula ulmaria (L.) Maxim. , Spiraea ulmaria L.
  • Filipendulae ulmariae herba
  • Meadowsweet
  • Common cold, supportive therapy;

REFERENCES:

– Csedö K, Monea M, Sabau M, Esianu S. The antibiotic activity of Filipendula ulmaria. Planta Med 1993;59(Suppl):A675. http://dx.doi.org/10.1055/s-2006-959953
– Denev P, Maria Kratchanova, Milan Ciz, Antonin Lojek, Ondrej Vasicek, Denitsa
Blazheva, et al. Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. Acta Biochim Pol 2014;61(2):359-67.
– Drummond EM, Harbourne N, Marete E, Martyn D, Jacquier JC, O`Riordan D, Gibney ER. Inhibition of proinflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark. Phytother Res 2013;27:588-94. http://dx.doi.org/10.1002/ptr.4753
– Fecka I. Qualitative and quantitative determination of hydrolysable tannins and other polyphenols n herbal products from meadowsweet and dog rose. Phytochem Anal 2009; 20:177-90. http://dx.doi.org/10.1002/pca.1113
– Halkes SBA, Beukelman CJ, Kroes BH, van den Berg AJJ, Labadie RP, van Dijk H. In vitro immunomodulatory activity of Filipendula ulmaria. Phytotherapy Res 1997a;11:518-20. http://dx.doi.org/10.1002/(SICI)1099-1573(199711)11:7<518::AID-PTR136>3.0.CO;2-9

 

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