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The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety to support the therapeutic uses of pelargonium.
This herbal drug by definition consists of pelargonium root, dried, unpeeled, usually fragmented, underground organs of Pelargonium sidoides and / or Pelargonium reniforme.
Studies with its main characteristic constituents proanthocyanidins and phenolic acids are included.
The therapeutic indications of pelargonium root are symptoms of upper respiratory tract infections including common cold, such as blocked or runny nose, sore throat and cough.
Administration of pelargonium root addresses dosage; duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; use during pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose.
In vitro experiments with pelargonium root demonstrated its antibacterial and immunomodulatory properties.
In vivo experiments with mice investigated anti-influenza virus activity of a pelargonium root extract.
Controlled clinical studies in humans with pelargonium root liquid extract, demonstrated symptomatic relief in acute bronchitis, in rhinosinusitis and the common cold.
Preclinical safety data were assessed in toxicity studies.
Human safety data were assessed in clinical studies, where gastrointestinal complaints and allergic skin reactions were reported.
The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of pelargonium root and its constituents. Examples are given below.
- Pelargonium sidoides DC.; Pelargonium reniforme Curt.
- Pelargonii radix
- Pelargonium root
- Common cold, blocked or runny nose; Sore throat; Cough.
EXAMPLE OF REFERENCES:
– Kolodziej H, Schulz V. Umckaloabo — Von der traditionellen Anwendung zum modernen Phytotherapeutikum. Dtsch Apoth Ztg 2003;143:1303-12.
– Luna LA, Bachi ALL, Novaes e Brito RR, Eid RG, Suguri VM, Oliveira PW, Gregorio LC, Vaisberg M. Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of athletes after exhaustive exercise: modulation of secretory IgA, IL-6 an IL-15. Phytomedicine 2011;18:303-8. http://dx.doi.org/10.1016/j.phymed.2010.08.003
– Neugebauer P, Mickenhagen A, Siefer O, Walger M. A new approach for pharmacological effects on ciliary beat frequency in cell cultures – exemplary measurements under Pelargonium sidoides extract (Eps 7630). Phytomedicine 2005;12:46-51. http://dx.doi.org/10.1016/j.phymed.2003.11.005
– Nöldner M and Schölz K. Inhibition of lipopolysaccharide-induced sickness behaviour by a dry extract from the roots of Pelargonium sidoides (EPs 7630) in mice. Phytomedicine 2007, 14 (Suppl VI):27-31. http://dx.doi.org/10.1016/j.phymed.2006.11.013
– Theisen LL, Muller CP. EPs® 7630 (Umckaloabo), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. Antiviral Research 2012;94:147-56. http://dx.doi.org/10.1016/j.antiviral.2012.03.006