Rhatany Root – ESCOP Herbal Monograph

Ratanhiae radix
Rhatany Root
Krameria triandra Ruiz et Pav.,
Published 2017

Price: €20
Format: PDF; Instant Download







The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety to support the therapeutic uses of rhatany root.

This herbal drug by definition consists of the dried, usually fragmented, underground organs of Krameria triandra Ruiz et Pav., this is considered to be a synonym of Krameria lappacea (Dombey) Burdet & B.B.Simpson.

Studies with its main characteristic constituents complex polyphenols (proanthocyanidins) and lignans are included.

The therapeutic indications are minor inflammations of the mouth and throat such as stomatitis, gingivitis and pharyngitis.

Administration of rhatany root addresses posology; its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose.

In vitro and in vivo experiments with rhatany root and its extracts demonstrate anti-inflammatory, antimicrobial and astringent properties.

Preclinical safety data were assessed in toxicity studies.

The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of rhatany root and its major constituents. Examples are given below.


  • Krameria triandra Ruiz & Pav.. Krameria lappacea (Dombey) Burdet & B.B.Simpson
  • Ratanhiae radix
  • Rhatany root
  • Stomatitis, minor inflammation; Gingivitis, minor inflammation; Pharyngitis, minor inflammation


– Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J et al. Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro. J Nat Prod 2011; 74: 1779–1786.

 – De Bellis P, Griffini A, Peterlongo F. Identification of the main neolignan constituents of rhatany (Krameria triandra roots) by HPLC-MS and GC-MS. Fitoterapia 1994; 65: 503-14.

– Neto CC, Owens CW, Langfield RD, Comeau AB, St. Onge J, Vaisberg AJ, Hammond GB. Antibacterial activity of some Peruvian medicinal plants from the Callejon de Huaylas. J Ethnopharmacol 2002; 79: 133-8.  http://dx.doi.org/10.1016/S0378-8741(01)00398-1

– Scholz E, Rimpler H. Proanthocyanidins from Krameria triandra root. Planta Med 1989;55:379-84.


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