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The herbal monograph selects and summarises scientific studies and textbooks regarding efficacy, dosage and safety to support the therapeutic uses of tormentil. This herbal drug by definition consists of the whole or cut, dried rhizome, freed from the roots, of Potentilla erecta (L.) Raeusch., P. tormentilla Stokes). Studies with its main characteristic constituents tannins, phenolic acids and triterpene saponins are included. The therapeutic indications are non-specific, acute diarrhea, adjuvant treatment of acute and subacute enteritis and colitis and slight irritations of the mucosa of mouth and throat. Administration of tormentil addresses dosage, its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose. In vitro experiments with tormentil extracts demonstrate astringent, antibacterial and antioxidant properties. In vivo experiments with tormentil constituents indicate hypoglycaemic and antitumour properties. Controlled human clinical studies with a tormentil extract demonstrated its use in patients with rotavirus diarrhea. Preclinical safety data for tormentil were assessed in acute toxicity studies. Safety data were assessed in human studies, where no severe clinical side effects were observed. The selection of literature cited in the monograph is aimed at bringing together relevant information about the possible physiological roles of tormentil and its major constituents. Examples are given below.
- Potentilla erecta (L.) RAEUSCH.; Potentilla tormentilla STOKES.
- Tormentillae rhizome
- Diarrhoea acute; Enteritis; Colitis; Irritation of mouth mucosa